Monday, October 21, 2013

Paget's Disease of Bone

Osteitis deformans


Special Characteristics

  • Bones grow too large and weak
  • Most commonly found in the spine, skull, pelvis, and legs
  • More common in males than females and older than younger

Causes

  • Disruption in the process of new bone removing and replacing old bone
  • Exact cause unknown, though scientists have found a correlation between Paget's Disease of Bone and select genotypes

Signs and Symptoms

  • Pain
  • Enlarged bones
  • Broken bones
  • Damaged cartilage in joints
  • May result in bone growth deformities, such as bowed legs

Diagnosis

  • X-rays and blood tests
  • Presence on elevated alkaline phosphatase

Treatment

  • Medicines and surgery
  • Biophosphonates help to strengthen bones weakened by osteoporosis
  • Maintaining a healthy habit of exercise and diet

References

“Cotton Wool” Appearance of Paget's Disease. (n.d.). The New England Journal of Medicine. Retrieved October 13, 2013, from http://www.nejm.org/doi/full/10.1056/NEJMicm0912945
Bowed legs from Paget's disease. (n.d.). WebMD - Better information. Better health.. Retrieved October 13, 2013, from http://www.webmd.com/a-to-z-guides/bowed-legs-from-pagets-diseasePaget's Disease of Bone: MedlinePlus. (n.d.). National Library of Medicine - National Institutes of Health. Retrieved October 13, 2013, from http://www.nlm.nih.gov/medlineplus/pagetsdiseaseofbone.htmlPaget's disease of bone - MayoClinic.com. (n.d.). Mayo Clinic. Retrieved October 13, 2013, from http://www.mayoclinic.com/health/pagets-disease-of-bone/DS00485 

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